NCT01455207

From Uncomplicated Alcoholism to Korsakoff's Syndrome

From Uncomplicated Alcoholism to Korsakoff's Syndrome: Clinical, Genetic, Neuropsychological and Brain Examinations

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 220 (estimated)
• Sponsor: University Hospital, Caen · Academic / Other
• Sex: All
• Age: 21 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This research project aims to identify factors that contribute to the heterogeneity observed in neuroradiological and neuropsychological signs of chronic alcoholism. The investigators overarching hypothesis is that the heterogeneity of alcoholic consequences on brain structure and metabolism, and cognition is mainly related to individual differences in pattern of alcohol use, gene pool, nutritional status and history of withdrawal symptoms.

Conditions

• Alcoholism
• Alcohol Amnestic Disorder

Interventions

Type	Name	Description
BEHAVIORAL	Neuropsychological testing	assessment of memory, executive functions and ataxia
BIOLOGICAL	blood draw	hepatic markers, red blood markers and vitamin markers
GENETIC	genetic testing	genes coding for thiamine enzymes (α-ketoglutarate dehydrogenase complex, transketolase et pyruvate dehydrogenase)
OTHER	Brain imaging examination	MRI, DTI and PET examinations

Timeline

• Start date: 2012-01-01
• Primary completion: 2015-01-01
• Completion: 2015-01-01
• First posted: 2011-10-19
• Last updated: 2014-04-09

Locations

1 site across 1 country: France