NCT01435681

Can Short Latency Afferent Inhibition Give us Clues to Better DYT 1 Dystonia Treatments?

Can Short Latency Afferent Inhibition Give us Clues to Better Dystonia Treatments?

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 5 (actual)
• Sponsor: University of Florida · Academic / Other
• Sex: All
• Age: 10 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This is a research study using transcranial magnetic stimulation (TMS) to investigate interactions between the sensory system and the motor cortex in primary generalized dystonia (DYT1 dystonia) subjects who undergo deep brain stimulation (DBS) surgery. The sensory system is the body's sense organs - smell, sight, sound, etc. - and the motor cortex is the part of your brain where nerve impulses control voluntary muscle activity.

Detailed description

The cause of DYT1 dystonia is not clear. DYT1 dystonia symptoms include abnormal posture or repetitive twisting movements affecting one body part; in some patients, the entire body can twist and contort painfully. Magnetic resonance imaging (MRI) studies are normally used to evaluate changes in brain structure in DYT1 dystonia. Transcranial magnetic stimulation (TMS) is a painless, non-invasive method to test how your brain conducts electrical messages to the rest of your body, including your muscles. If you are a DYT1 dystonia patient, then this study involves up to three visits. The first visit (before DBS surgery) will last about 4 hours and the second and third visits (after DBS surgery) will last about 4 hours as well. These visits will include a complete physical and neurological exam, video recorded dystonia and mood rating scales, followed by electromyography (EMG) and TMS sessions. Subjects who have already undergone DBS surgery may participate in applicable visits based on the length of time since their DBS surgery. If you are a control subject, this study involves one visit, about 4 hours long. This visit will include TMS and EMG sessions.

Conditions

• DYT-1
• DYT1
• DYT 1
• Dystonia

Timeline

• Start date: 2012-05-01
• Primary completion: 2014-10-01
• Completion: 2016-08-01
• First posted: 2011-09-19
• Last updated: 2016-09-08

Locations

1 site across 1 country: United States