NCT01421420

Alzheimer's Disease Core Center

Arizona Alzheimer's Disease Core Center

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 900 (estimated)
• Sponsor: University of Arizona · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Accepted

Summary

The main objective of this research project is to provide a comprehensive clinical database of patients with Alzheimer's disease (AD) and other forms of dementia, individuals with mild cognitive impairment (MCI), and age-matched normal controls. The study will also attempt to identify cognitively normal individuals at genetically defined risk for Alzheimer's disease through genetic screening. All participants are seen annually. Autopsies to establish diagnoses in patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.

Detailed description

All participants are seen annually. In addition to a detailed neurological examination, participants will receive a standardized battery of neuropsychological tests and will undergo genetic testing. The investigators will provide standardized periodic longitudinal assessment of the research participants. Autopsies to establish neurohistopathological diagnoses in clinically well-characterized patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.

Conditions

• Alzheimer's Disease
• Mild Cognitive Impairment
• Age-Related Memory Disorders

Timeline

• Start date: 2001-07-01
• Primary completion: 2024-12-01
• Completion: 2025-07-01
• First posted: 2011-08-22
• Last updated: 2015-06-12

Locations

1 site across 1 country: United States