NCT01420406

Vitamin A Bioavailability in Lactating Women With Marginal Vitamin A Status

Impact of Daily Feeding of Food Sources of Cryptoxanthin (CX) and Beta-carotene (BC) on Plasma and Breast Milk Concentrations of CX, BC, and Retinol (VA) in Lactating Women With Marginal Vitamin A Status

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 140 (actual)
• Sponsor: USDA, Western Human Nutrition Research Center · Federal
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The study will assess the relative bioavailability and bioefficacy of cryptoxanthin (CX) and beta-carotene (BC) from food sources for increasing breast milk carotenoid and retinol concentrations in lactating Bangladeshi women.

Detailed description

The specific aim is to compare the effects of orange-fleshed sweet potatoes and tangerines compared to white-fleshed sweet potatoes and vitamin A as retinyl palmitate on blood and breast milk cryptoxanthin (CX), beta-carotene (BC), and vitamin A (VA) concentrations by randomly assigning lactating Bangladeshi women to one of four treatment groups for 6 days/week for 3 weeks. The investigators will also compare the relative vitamin A (VA) value of BC and CX from food sources by comparing the mean change in breast milk retinol concentrations of the groups that receive tangerines (CX) or orange-fleshed sweet potatoes (BC) with the mean change in breast milk retinol of the group that receives retinyl palmitate.

Conditions

• Vitamin A Deficiency

Interventions

Type	Name	Description
OTHER	0 mg retinol activity equivalents	0 mg retinol activity equivalents (RAE) as white-fleshed sweet potatoes and a corn oil capsule
OTHER	12 mg of BC	12 mg of BC as orange-fleshed sweet potatoes and a corn oil capsule
OTHER	6 mg of CX	6 mg of CX as tangerines and a corn oil capsule
OTHER	1.0 mg RAE	1.0 mg RAE vitamin A as retinyl palmitate in corn oil, and white-fleshed sweet potatoes

Timeline

• Start date: 2010-06-01
• Primary completion: 2011-05-01
• Completion: 2012-06-01
• First posted: 2011-08-19
• Last updated: 2012-09-12

Locations

1 site across 1 country: Bangladesh