NCT01412320

Cocoa Flavanols in Renal Disease

The Impact of Dietary Flavanols on Cardiovascular Dysfunction in End-stage Renal Disease

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: Klinik für Kardiologie, Pneumologie und Angiologie · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Purpose of the study is to characterize the potential acute and long-term improvement of dietary flavanols on vascular function in patients with end-stage renal disease (ESRD). Patients will twice daily receive either a flavanol-poor or a flavanol-rich drink. In a double blind, placebo-controlled crossover study the safety, efficacy and acute beneficial effects of flavanol ingestion will be assessed in 10 patients with ESRD. In a 30 day long-term, double blind, placebo-controlled parallel study the chronic effects of dietary flavanols on vascular function in 52 patients with ESRD will be evaluated.

Conditions

• End Stage Renal Disease
• Endothelial Dysfunction

Interventions

Type	Name	Description
OTHER	Cocoa	dissolved in water twice daily
OTHER	Cocoa	dissolved in water twice daily

Timeline

• Start date: 2011-08-01
• Primary completion: 2012-12-01
• Completion: 2012-12-01
• First posted: 2011-08-09
• Last updated: 2013-11-13

Locations

1 site across 1 country: Germany