NCT01391039

Diagnostic Study of Early Breast Cancer Using Ultrasound

Microbubble Contrast Ultrasound and Transient Elastography Imaging of Early Breast Cancer

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Sunnybrook Health Sciences Centre · Academic / Other
• Sex: Female
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This is a pilot study designed to investigate new techniques to guide the appropriate diagnosis and treatment of Ductal Carcinoma In-situ (DCIS). The microvascularity and stiffness of the lesion may be prognostic factors that can guide the need for more or less extensive therapy or perhaps only imaging follow-up may be needed.

Detailed description

Women who have imaging findings suggestive of DCIS, who are having breast ultrasound and who are candidates for surgery will be eligible. They will receive a contrast-enhanced breast ultrasound after the intravenous injection of a microbubble contrast agent which will show the microvascularity. A subset of women will also have ultrasound elastography performed of the abnormality to evaluate its stiffness.

Conditions

• Ductal Carcinoma In-situ

Interventions

Type	Name	Description
DRUG	Perflutren lipid microsphere	Intravenous injection of 10 microL/kg once prior to ultrasound examination

Timeline

• Start date: 2011-09-01
• Primary completion: 2015-07-01
• Completion: 2015-07-01
• First posted: 2011-07-11
• Last updated: 2015-11-30

Locations

1 site across 1 country: Canada