NCT01349439

Reducing Reconsolidation of Trauma Memories With Propranolol

Reduction of the Reconsolidation of the Trauma Memory With Propranolol

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 76 (estimated)
• Sponsor: Douglas Mental Health University Institute · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to test whether propranolol is capable of reducing subsequent physiological trauma-related conditioned responses, as well as self-reported post-traumatic stress disorder (PTSD) symptoms.

Conditions

• Posttraumatic Stress Disorder

Interventions

Type	Name	Description
DRUG	Propranolol	1mg per Kg (participant weight)
DRUG	Short acting + long acting propranolol + memory reactivation	After completing the double-blind phase of the study, participants will receive short acting propranolol 1mg/kg (patient weight) + long acting propranolol (1 or 1.5 mg/kg) followed by memory reactivation. Dose level for the long-acting propranolol will be randomly assigned across participants.

Timeline

• Start date: 2011-03-01
• Primary completion: 2015-01-01
• First posted: 2011-05-06
• Last updated: 2014-06-24

Locations

1 site across 1 country: Canada