NCT01343862

The Effect of Single Dose D-Cycloserine on Cognitive Outcome in Moderate Traumatic Brain Injury (TBI) Patients

The Effect of Single Dose D-Cycloserine on Cognitive Outcome in Moderate TBI Patients

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Hadassah Medical Organization · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

In this study of patients with moderate traumatic brain injury with frontal brain contusions patients will be randomized to treatment with a single dose of either D-cycloserine or placebo given 48-72 hours after injury. Patients will undergo intensive neurocognitive testing at 3 and 6 months after injury to assess whether treatment with a single dose of D-cycloserine improves cognitive outcome after moderate brain injury.

Conditions

• Traumatic Brain Injury

Interventions

Type	Name	Description
DRUG	D-cycloserine	single dose of D-cycloserine given 48-72 hours after moderate traumatic brain injury
DRUG	placebo	A sugar pill will be given to those patients randomized to the control group at 48-72 hours after moderate brain injury

Timeline

• Start date: 2011-08-01
• Primary completion: 2014-05-01
• Completion: 2014-05-01
• First posted: 2011-04-28
• Last updated: 2011-04-28

Locations

3 sites across 1 country: Israel