NCT01339065

The Effect of Ketamine on Production of Inflammatory Markers in Post Operative Patients in Mulago Hospital

The Effect of Ketamine on Production of Inflammatory Markers in Post Operative Patients in Mulago Hospital: A Randomized Clinical Trial

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Makerere University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

. Null Hypothesis: Giving low doze ketamine (0.5mg/kg) given preoperatively to adult patients undergoing elective surgery, in Mulago hospital, will not have a reduction effect on the levels of IL-6 \& IL-1β pro inflammatory markers by 48 hours. . Alternate Hypothesis: Giving low doze ketamine (0.5mg/kg) given preoperatively to adult patients undergoing elective surgery, in Mulago hospital, will have a reduction effect on the levels of IL-6 \& IL-1β pro inflammatory markers by 48 hours.

Detailed description

RESEARCH QUESTION Can 0.5mg/kg of Ketamine given preoperatively have an effect on the levels of pro-inflammatory markers? Primary specific Outcome: changes/deviations from baseline levels of IL- 6 pro-inflammatory markers of after surgery at PACU, 24 and 48 hours. Secondary specific Outcome: changes/deviations from baseline levels of IL-1β pro-inflammatory markers of after surgery at PACU, 24 and 48 hours.

Conditions

• Post Operative Inflammatory Marker Levels

Interventions

Type	Name	Description
DRUG	Ketamine	determining the effect of low dose sub anesthetic doze of ketamine and placaebo on post operative patients

Timeline

• Start date: 2011-04-01
• Primary completion: 2011-05-01
• Completion: 2011-06-01
• First posted: 2011-04-20
• Last updated: 2011-04-20

Locations

1 site across 1 country: Uganda