NCT01332812

Dexamethasone for the Prevention of Postoperative Cognitive Dysfunction

Dexamethasone for the Prevention of Postoperative Cognitive Dysfunction in Elderly Patients Undergoing to General Anesthesia

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 300 (actual)
• Sponsor: University of Sao Paulo · Academic / Other
• Sex: All
• Age: 60 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

This study aims to evaluate the possible effect of dexamethasone on prevention of cognitive dysfunction in the postoperative period of elderly patients undergoing to surgery under general anesthesia.

Detailed description

Postoperative cognitive dysfunction is related with the use of opioids in the postoperative period, lack of physical activity, fatigue, postoperative pain and quality of life. The use of corticosteroids preoperatively reduces postoperative pain, fatigue, nausea and vomiting in the postoperative period and is frequently used as an adjuvant in anesthesia. This study aims to evaluate the possible effect of dexamethasone on prevention of cognitive dysfunction in the postoperative period of elderly patients undergoing to surgery under general anesthesia.

Conditions

• Postoperative Cognitive Dysfunction

Interventions

Type	Name	Description
DRUG	Dexamethasone	a dose of 8 mg of dexamethasone will be administered intravenously before induction of general anesthesia
OTHER	control group	General anesthesia, without additional interventions

Timeline

• Start date: 2011-01-01
• Primary completion: 2013-02-01
• Completion: 2013-03-01
• First posted: 2011-04-11
• Last updated: 2015-09-10

Locations

1 site across 1 country: Brazil