NCT01326741

Clonal Mast Cell Disorders in Exercise-Induced Anaphylaxis

Detection of Clonal Mast Cell Disorders Among Patients With Exercise-induced Anaphylaxis

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 10 (estimated)
• Sponsor: Brigham and Women's Hospital · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Not accepted

Summary

Anaphylaxis is a serious allergic reaction that develops rapidly and can cause death. Some patients experience anaphylaxis is association with exercise, a disorder called exercise-induced anaphylaxis. A subset of patients with unexplained anaphylaxis, especially those with hypotension during the anaphylactic episodes, have been shown to have abnormal, clonal populations of a certain cell type, mast cells, in the bone marrow. This has been described in at least one patient with exercise-induced anaphylaxis. The investigators would like review the findings in a group of patients with exercise-induced anaphylaxis who have undergone evaluation for the presence of abnormal, clonal mast cells.

Conditions

• Anaphylaxis

Timeline

• Start date: 2011-03-01
• First posted: 2011-03-31
• Last updated: 2011-03-31

Locations

1 site across 1 country: United States