NCT01307202

Morphine Consumption in Joint Replacement Patients, With or Without Gabapentin Treatment

Multiple Doses of Gabapentin and Postoperative Morphine Consumption in Total Knee Arthroplasty

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 101 (actual)
• Sponsor: McMaster University · Academic / Other
• Sex: All
• Age: 19 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Total knee arthroplasty is amongst the most painful procedures postoperatively, and pain management can be a challenge. Different measures have been introduced to manage severe postoperative pain int hese patients. Previous studies have investigated gabapentin in acute postoperative pain and demonstrated reducted pain, postoperative morphine consumption, morphine related side effects, and postoperative pain scores. To date, this analgesia adjunct has yet to be investigated in total joint arthroplasty patients.

Detailed description

The study was submitted to Health Canada and received the letter of no objection. A randomized, double-blind, placebo-controlled study. The randomization scheme will be prepared and will be done by the pharmacy department at McMaster University. Ninety patients undergoing primary knee arthroplasty will be recruited from the preoperative clinic. Forty-five patients in each population will be allocated to a gabapentin group and the other forty-five to a placebo group.

Conditions

• Post Operative Pain
• Total Knee Replacement

Interventions

Type	Name	Description
DRUG	Gabapentin	600mg of Gabapentin will be given orally preoperatively and 200mg for 3 times a day after surgery for 3 days
DRUG	Placebo	Placebo will match the the gabapentin pill and will be given orally.

Timeline

• Start date: 2007-10-01
• Primary completion: 2011-02-01
• Completion: 2011-02-01
• First posted: 2011-03-02
• Last updated: 2014-11-20

Locations

1 site across 1 country: Canada