NCT01288924

Can Parecoxib Reduce Post-operative Ipsilateral Shoulder Pain?

Can Preemptive Analgesia With Parecoxib Reduce Post-operative Ipsilateral Shoulder Pain? A Double-blinded, Randomized, Placebo-controlled Trial.

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 160 (actual)
• Sponsor: Chiang Mai University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare the efficacy of parecoxib with placebo on the incidence and severity of postthoracotomy shoulder pain, the amount of analgesic requirement for relieving severity of postthoracotomy shoulder pain and adverse events associated with treatment.

Detailed description

The incidence of Post-operative Ipsilateral Shoulder Pain (PISP) varies from 21-97% after thoracic surgery, despite receiving effective thoracic epidural analgesia. This pain has been described as constant, aching in quality, unrelated to position change or respiration. Possible causes of shoulder pain includes injury of the phrenic nerve, the lateral decubitus position, transection of major bronchus or preexisting arthritis condition. The possibilities of prevention and management of PISP are taken into consideration. Thoracic epidural block will be performed in all patients before general anesthesia.

Conditions

• Shoulder Pain
• Post-operative Pain

Interventions

Type	Name	Description
DRUG	Parecoxib	Parecoxib 40 mg intravenous before surgery and every 12 hours for two days.
OTHER	Control	NSS 2 ml intravenous before surgery and every 12 hours for two days.

Timeline

• Start date: 2011-02-01
• Primary completion: 2015-10-01
• Completion: 2016-01-01
• First posted: 2011-02-03
• Last updated: 2016-12-06

Locations

2 sites across 1 country: Thailand