NCT01280162

Malaria Active Epidemiology and Treatment Study

An Active Malaria Epidemiology Cohort Study With Evaluation of a 2 Day Versus 3 Day Treatment Regimen of Dihydroartemisinin (DHA)-Piperaquine for Patients With Uncomplicated Malaria

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 222 (actual)
• Sponsor: Armed Forces Research Institute of Medical Sciences, Thailand · Other Government
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

An observational cohort and malaria treatment study in Cambodia.

Detailed description

This is an active observational Cohort Study of malaria epidemiology with a nested two arm, randomized, open label Treatment Study comparing the efficacy, safety, tolerability and pharmacokinetics of a two versus three day course of Dihydroartemisinin-Piperaquine (DP) for those developing uncomplicated malaria. At the conclusion of the Cohort Study, a subset of volunteers with documented exposure to Plasmodium vivax during the study will be treated with primaquine as presumptive anti-relapse therapy directed against the exoerythrocytic malaria stages of P. vivax, and followed passively for an additional 6 months.

Conditions

• Malaria

Interventions

Type	Name	Description
DRUG	Dihydroartemisinin piperaquine	40/320 mg tablets, 9 tablets total

Timeline

• Start date: 2010-09-01
• Primary completion: 2011-02-01
• Completion: 2012-12-01
• First posted: 2011-01-20
• Last updated: 2021-03-03

Locations

1 site across 1 country: Cambodia