NCT01270542

Avastin for PDR (Proliferative Diabetic Retinopathy)

Effect of Pre-operative Adjunctive Anti-VEGF on Growth Factors in Severe Proliferative Diabetic Retinopathy Requiring Surgical Management

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University of Southern California · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the effect of anti-VEGF drug (Avastin) adminstration in eyes prior to surgical treatment for Traction retinal detachment (TRD) in patients with Proliferative Diabetic Retinopathy (PDR).

Detailed description

Traction retinal detachment (TRD) due to proliferative diabetic retinopathy is a blinding disease caused by contraction of fibrovascular proliferation, treatment of which is limited to surgery. Fibrosis and neovascularization are both associated with high levels of connective tissue growth factor (CTGF) and vascular endothelial growth factor (VEGF) in the eye. Small, nonrandomized studies have suggested that pre-operative adjunctive anti-VEGF administration may reduce intra- and post-operative complications and provide visual benefit in patients with this condition.

Conditions

• Retinal Detachment
• Diabetic Retinopathy

Interventions

Type	Name	Description
DRUG	Avastin (bevacizumab)	single 0.05 mL intravitreal injection of bevacizumab 1.25 mg
OTHER	Sham injection	Subject's eyes will be anesthetized but no injection will be performed.

Timeline

• Start date: 2009-06-01
• Primary completion: 2011-07-01
• Completion: 2012-07-01
• First posted: 2011-01-05
• Last updated: 2017-08-17
• Results posted: 2017-08-17

Locations

1 site across 1 country: United States