NCT01263574

Trial of 70% Ethanol Versus Heparin to Reduce the Rate of Central Line Infections in Children With Short Bowel Syndrome

Trial of Ethanol Lock Therapy to Prevent Catheter Associated Blood Stream Infections

• Status: Withdrawn
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Boston Children's Hospital · Academic / Other
• Sex: All
• Age: 3 Months
• Healthy volunteers: Accepted

Summary

This study is designed to determine if the use of 70% ethanol lock solution in central lines decreases the rate of central line infections in children with short bowel syndrome. While ethanol locks have been used safely in children, there has been no published research to date that clearly shows it is of definite benefit in this group of patients.

Conditions

• Catheter Related Infections
• Short Bowel Syndrome

Interventions

Type	Name	Description
DRUG	70% ethanol	Administration of the lock solution will occur between cycles of parenteral nutrition. Lock solutions will be administered three days per week. The pre-measured volume of lock solution will then be injected into the catheter for 4 hours. Prior to the next instillation of medications into the catheter, the lock solution will be aspirated and discarded. Another 5mL flush of saline will then be instilled into the catheter prior to medication or parenteral nutrition administration. Volume of lock solution administered will be determined by catheter size.

Timeline

• Start date: 2011-02-01
• Primary completion: 2012-06-01
• Completion: 2012-09-01
• First posted: 2010-12-20
• Last updated: 2017-06-22

Locations

1 site across 1 country: United States