NCT01260428

Effects of Expiratory Pressure on Arterial Oxygenation During Hypoxia

Arterial Oxygenation During Hypoxia : Effects of an Added Expiratory Resistance

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: AGIR à Dom · Academic / Other
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Altitude tolerance correlates with the level of oxygenation achieved. The aim of the present study is to investigate whether increased expiratory pressure within the thorax is able to improve oxygenation during hypoxic hypoxia.

Detailed description

Two types of procedures will be tested in a random order, interspaced by resting periods : threshold PEEP set at 5,10 and 15 cm of water and pursed leap breathing. Subjects will be tested at rest, and during light exercise (30% of sea level predicted VO2max). FiO2 will be set at 12.5% (4000 m). fc, VE, PETCO2, TA, ECG, cardiac output, and tissular oxygenation will be monitored.

Conditions

• Hypoxia

Interventions

Type	Name	Description
DEVICE	threshold PEEP	Various set of pressures : 0, 5, 10 cm H20; pursed lips breathing

Timeline

• Start date: 2011-02-01
• First posted: 2010-12-15
• Last updated: 2012-02-28

Locations

1 site across 1 country: France