NCT01250925

Effect of Contact Lens Wear on Immune Cell Density and Morphology of the Ocular Surface

Effect of Contact Lens Wear on Immune Cell Density and Morphology of the Ocular Surface: A Laser In Vivo Confocal Microscopy Study

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 94 (actual)
• Sponsor: Massachusetts Eye and Ear Infirmary · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to utilize in-vivo confocal microscopy to describe differences in corneal epithelial immune status across three lens care regimens in new contact lens wearers.

Detailed description

An estimated 40 million people in the United States wear contact lenses, with approximately 38 million soft lens wearers and 2 million rigid gas permeable lens wearers. The ocular surface has been shown to respond to the introduction of foreign materials with upregulation of proinflammatory mediators, leading to an increase in inflammation. The corneal can show a foreign body immune response to contact lenses. The purpose of this study is to utilize in-vivo confocal microscopy to describe differences in corneal epithelial immune status across the three lens care regimens in new contact lens wearers.

Conditions

• Myopia
• Refractive Error

Interventions

Type	Name	Description
DRUG	ReNu MultiPlus® MultiPurpose Solution	Contact lens care regimen
DRUG	OPTI-FREE® RepleniSH®	Contact Lens care regimen
DRUG	Clear Care®	Contact lens care regimen

Timeline

• Start date: 2010-08-01
• Primary completion: 2012-02-01
• Completion: 2012-07-01
• First posted: 2010-12-01
• Last updated: 2017-01-10
• Results posted: 2017-01-10

Locations

2 sites across 1 country: United States