NCT01248104

Comparison of Tranexamic to Epsilon Aminocaproic Acid: a Prospective Analysis of Blood Conservation in Cardiac Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Loma Linda University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

We designed a prospective double-blinded randomized trial in an attempt to detect a difference between tranexamic acid (TXA) and epsilon aminocaproic acid (EACA) in reducing transfusion in patients undergoing cardiac surgery.

Detailed description

Background: This study compares the efficacy of tranexamic acid (TXA) to epsilon aminocaproic acid (EACA) in reducing blood loss in patients undergoing cardiac surgery. Methods: This was a double-blinded randomized trial. Patients (n=100) undergoing cardi- ac surgery were randomized to receive either TXA (10 mg/kg bolus followed by an infu- sion of 1mg/kg/hr) or EACA (150mg/kg bolus followed by an infusion of 20 mg/kg/hr). The primary outcome measure was a difference in transfusion amounts.

Conditions

• Cardiopulmonary Bypass

Interventions

Type	Name	Description
DRUG	Tranexamic Acid	Infusion during cardiac surgery
DRUG	Aminocaproic Acid	Infusion during cardiac surgery

Timeline

• Start date: 2010-03-01
• Primary completion: 2013-03-01
• Completion: 2015-02-01
• First posted: 2010-11-25
• Last updated: 2020-10-19
• Results posted: 2020-08-26

Locations

1 site across 1 country: United States