NCT01243879

The Effect of Food Stimuli on the Calorie Restriction Response in Healthy Subjects

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Leiden University Medical Center · Academic / Other
• Sex: Male
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Calorie restriction extends life span and prevents aging-related diseases in several species. Odorants from live yeast restrain the beneficial effects of calorie restriction in Drosophila Melanogaster. The investigators hypothesize that visual and odorous food stimuli impact the neuroendocrine and metabolic response to starvation in healthy humans. In this randomized cross-over intervention study 12 healthy, young men will fast twice for 60-hours in the presence or absence of food-related visual and odorous stimuli. At baseline and on the last morning of each intervention an oral glucose tolerance test (OGTT) will be performed. During the OGTT blood is sampled and hypothalamic neuronal activity is measured by functional MRI.

Conditions

• Calorie Restriction
• Aging

Interventions

Type	Name	Description
OTHER	Stimuli of food smell and vision	60 hours of starvation (fasting) in the presence or absence of visual and odorous food cues
OTHER	No stimuli of food smell and vision	60 hours of starvation (fasting) in the presence or absence of visual and odorous food cues

Timeline

• Start date: 2008-07-01
• Primary completion: 2009-03-01
• Completion: 2009-03-01
• First posted: 2010-11-19
• Last updated: 2020-02-21