NCT01237275

Development of A Technique to Predict Antidepressant Responsiveness in Depressive Patients

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: Samsung Medical Center · Academic / Other
• Sex: All
• Age: 19 Years – 89 Years
• Healthy volunteers: Accepted

Summary

First, the investigators examined the functional relevance of serotonin transporter polymorphisms by quantifying the activity of serotonin transporter in blood platelets of genotyped healthy volunteers and patients with major depression. Second, the investigators studied response to SSRIs in relation to 5-HTTLPR genotype and also to the functional expression of 5-HTT in platelets.

Detailed description

The purpose of this study is 1. to determine whether serotonin transporter genotypic or functional differences between depressive patients and normal controls were existed. 2. to determine the relationship between serotonin transporter polymorphisms and serotonin transporter functional expression. 3. to determine whether genomic or functional differences between drug responders and nonresponders predict the response of antidepressant

Conditions

• Depression
• Continuous Antidepressant Abuse
• Adverse Reaction to Drug

Interventions

Type	Name	Description
DRUG	SSRI treated group	characterize in arm of a study (SSRI treated group)

Timeline

• Start date: 1999-10-01
• Primary completion: 2003-12-01
• Completion: 2016-12-01
• First posted: 2010-11-09
• Last updated: 2015-12-31

Locations

1 site across 1 country: South Korea