NCT01236508

Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Ottawa Heart Institute Research Corporation · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Not accepted

Summary

The investigators hypothesize that inflammation in carotid plaque is predictive of the extent of ischemic lesion burden on the brain and will add to risk stratification for individuals with carotid disease.

Detailed description

Objectives: 1. To investigate the relationship of carotid inflammation, as measured by FDG positron emission tomography (PET) to standardized uptake value in atherosclerotic plaque, with the number of covert brain infarcts. 2. To investigate the relationship of FDG PET standardized uptake value with the relative volume of white matter hyperintensity. 3. To correlate vascular inflammation in the entire aorta and aortoiliac vessels to carotid inflammation and cerebral infarcts and white matter disease.

Conditions

• TIA
• Stroke
• Carotid Artery Stenosis

Interventions

Type	Name	Description
RADIATION	PET/CT imaging with F-18 fluorodeoxyglucose	Dose of 5 MBq/kg F-18-FDG given to fasting participant. Nuclear whole body imaging starting at 3 hours post-injection. The relation of the PET/CT image results and both the number of covert brain infarcts and the extent of white matter MRI hyperintensity will be investigated.

Timeline

• Start date: 2010-11-01
• Primary completion: 2016-10-27
• Completion: 2016-10-27
• First posted: 2010-11-08
• Last updated: 2017-04-24

Locations

1 site across 1 country: Canada