NCT01199107

Maximizing Treatment Outcome and Examining Sleep in Post-traumatic Stress Disorder (PTSD)

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: Southern Methodist University · Academic / Other
• Sex: All
• Age: 18 Years – 54 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine the efficacy of exercise in comparison to wellness education to determine if they can improve the effects of prolonged exposure therapy (PE) in reducing symptoms of anxiety associated with Post-traumatic Stress Disorder (PTSD). In addition, the two strategies (i.e., exercise and wellness education) will be compared in terms of improvements in sleep as well as levels of brain-derived neurotrophic factor (BDNF). BDNF is a protein that helps to support the survival of existing neurons and stimulate the growth new neurons and synapses. BDNF is important to learning and memory in general and therefore may be associated with the learning and memory as it relates to PE and corresponding symptom PTSD improvement.

Conditions

• Post-Traumatic Stress Disorder

Interventions

Type	Name	Description
BEHAVIORAL	Prolonged Exposure	75-90 minute weekly psychotherapy sessions x 12 weeks, focused on gradually confronting distressing trauma-related memories and reminders
BEHAVIORAL	Exercise	30 minutes of moderate-intensity treadmill exercise prior to the Prolonged Exposure
BEHAVIORAL	Wellness Intervention	30 minutes of wellness education prior to Prolonged Exposure

Timeline

• Start date: 2010-09-01
• Primary completion: 2013-08-01
• Completion: 2013-08-01
• First posted: 2010-09-10
• Last updated: 2014-12-10

Locations

1 site across 1 country: United States