NCT01184638

Long-term Outcome of General Anesthesia on Dysgnosia

Long-term Outcome Followed-up of the Cognitive Disorders After General Anesthesia

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 10,000 (estimated)
• Sponsor: Nanjing Medical University · Academic / Other
• Sex: All
• Age: 10 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Cognitive disorders in patients underwent general anesthesia are discussed for decades, but whether there were precise relationship between general anesthesia and dysgnosia is yet to be guaranteed. Although controversial data reported from experimental studies in animals, the investigators still proposed that general anesthetics could impair the normally organized system of the central nervous system, which finally displayed a dysfunction of cognition after general anesthesia in a short- or long-term period. Therefore, different types of general anesthetics such as inhalational anesthetics and intravenous anesthetics, the investigators hypothesized, had a long-term influence on patients' cognitive ability.

Conditions

• Delirium,
• Dementia,
• Amnestic,
• Cognitive Disorders

Interventions

Type	Name	Description
DRUG	Sevoflurane	1-8% sevoflurane for maintaining the whole period of general anesthesia
DRUG	Propofol	1-4 mg/kg/h of propofol during the whole period of general anesthesia

Timeline

• Start date: 2010-08-01
• Primary completion: 2020-08-01
• Completion: 2020-08-01
• First posted: 2010-08-19
• Last updated: 2014-01-14

Locations

1 site across 1 country: China