NCT01170845

Effect of Neutrophil Elastase Inhibitor on Lung Injury After Esophagectomy

A Pilot Study of Effect of Neutrophil Elastase Inhibitor on Lung Injury After Esophagectomy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 31 (actual)
• Sponsor: Yokohama City University Medical Center · Academic / Other
• Sex: All
• Age: 55 Years – 77 Years
• Healthy volunteers: Not accepted

Summary

A neutrophil elastase inhibitor may have effect on suppression of the lung injury after thoransthoracic esophagectomy. The investigators hypothesized that postoperative complication, particularly respiratory complication may be reduced by neutrophil elastase inhibitor after esophagectomy.

Detailed description

The aim of this study was to clarify the usefulness of perioperative administration of sivelestat sodium hydrate, a selective inhibitor of neutrophil elastase in the pulmonary function, systemic inflammatory response, and the postoperative clinical course following video-assisted thoracoscopic esohpagectomy for esophageal cancer.

Conditions

• Esophageal Cancer

Interventions

Type	Name	Description
DRUG	sivelestat sodium hydrate	saline or sivelestat sodium hydrate intravenously for 7 days starting the beginning of surgery

Timeline

• Start date: 2007-03-01
• Primary completion: 2009-03-01
• Completion: 2009-03-01
• First posted: 2010-07-27
• Last updated: 2010-07-27

Locations

1 site across 1 country: Japan