NCT01161017

Mechanism-based Choice of Therapy for Pain: Can Successful Prevention of Migraine be Coupled to a Psychophysical Pain Modulation Profile?

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 67 (actual)
• Sponsor: Rambam Health Care Campus · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Mechanism-based choice of therapy for pain: Can successful prevention of migraine be coupled to a psychophysical pain modulation profile?

Conditions

• Migraine

Interventions

Type	Name	Description
DRUG	Amitriptyline	Initial dose of 12.5mg will be given for 2 days. Then, daily 25mg will be taken for additional 8 weeks
DRUG	Topiramate	For the first 5 days of treatment 25mg is prescribed and should be ingested in one evening dose. For another 5 days, 25g dose should be taken twice a day (morning and evening). For the next 5 days, morning dose will be 25mg; evening dose will be 50mg. For the remaining 6 weeks of treatment, a dose of 50mg twice a day will be advised

Timeline

• Start date: 2008-07-01
• Primary completion: 2014-05-01
• Completion: 2014-05-01
• First posted: 2010-07-13
• Last updated: 2017-10-11

Locations

1 site across 1 country: Israel