NCT01155830

Inflammatory Cytokine Quantification in Infants

Inflammatory Cytokine Quantification in Infants With Documented Sepsis, Congenital Diaphragmatic Hernia and/or ECMO Therapy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 21 (actual)
• Sponsor: University of Utah · Academic / Other
• Sex: All
• Age: 2 Months
• Healthy volunteers: Not accepted

Summary

This study proposes to quantify inflammatory cytokine profiles in three neonatal disease states, namely, neonatal sepsis, infants with a congenital diaphragmatic hernia defect, and infants suffering cardiopulmonary failure significant enough to require heart/lung bypass treatment with extracorporeal membrane oxygenation (ECMO).

Detailed description

Very small blood samples (500 microliters) will be collected serially in these patients and analyzed with current cytokine array technology. A convenience sample of 60 patients, 20 with each of these diagnoses, will be collected over a 2 year period. These data will provide baseline information for possible therapeutic intervention with agents that enhance or suppress specific mediators, or adjust mediator balance to promote patient healing.

Conditions

• Sepsis
• Congenital Diaphragmatic Hernia
• Neonatal Cardiopulmonary Failure

Timeline

• Start date: 2010-06-01
• Primary completion: 2013-05-01
• Completion: 2013-06-01
• First posted: 2010-07-02
• Last updated: 2015-05-04
• Results posted: 2015-05-04

Locations

2 sites across 1 country: United States