NCT01151839

A Trial to Compare Preoperative Chemoradiation and Surgery Versus Surgery Alone in Squamous Cell Carcinoma of Oesophagus

Preoperative Chemoradiation and Surgery Versus Surgery Alone in Squamous Cell Carcinoma of Oesophagus - A Randomized Controlled Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: All India Institute of Medical Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Carcinoma of the esophagus is the among the most common cancers in Indian population. While adenocarcinoma is more common in western countries, in India squamous cell carcinoma is the more frequent form. Surgery is the standard treatment in resectable lesions, but survival is poor. Adjuvant and neoadjuvant treatment therapy is used with an aim to improve the results. Though few randomized trials have addressed the issue of neoadjuvant chemoradiotherapy, the methodology was inhomogeneous and the populations studied were different. The investigators will be conducting a randomized controlled trial in patients with squamous cell carcinoma of the esophagus. Preoperative chemoradiation followed by surgery will be compared with surgery alone.

Conditions

• Esophageal Neoplasms

Interventions

Type	Name	Description
PROCEDURE	Esophagectomy	Patient with squamous cell carcinoma of esophagus will be treated with surgery alone
PROCEDURE	Neoadjuvant chemoradiation followed by surgery	Patient with squamous cell carcinoma of esophagus will be treated by neoadjuvant chemoradiation followed by surgery

Timeline

• Start date: 2010-06-01
• Primary completion: 2012-07-01
• First posted: 2010-06-29
• Last updated: 2010-07-12

Locations

1 site across 1 country: India