NCT01148992

Interactions Between Intravenous (IV) Cocaine and Lofexidine

Phase 1, Double-Blind, Placebo-Controlled Assessment of Potential Interactions Between Intravenous Cocaine and Lofexidine

• Status: Terminated
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: National Institute on Drug Abuse (NIDA) · NIH
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to assess potential interactions between intravenous (IV) cocaine and treatment with lofexidine.

Detailed description

To determine the safety of daily oral lofexidine alone and concurrent with IV cocaine infusions of 20 mg and 40 mg in cocaine-experienced, non-opiate-addicted volunteers.

Conditions

• Cocaine Related Disorders

Interventions

Type	Name	Description
DRUG	Lofexidine	0.8mg alone and concurrent with IV cocaine infusions of 20 mg and 40 mg
DRUG	Placebo	0mg

Timeline

• Start date: 2010-08-01
• Primary completion: 2010-12-01
• Completion: 2011-03-01
• First posted: 2010-06-23
• Last updated: 2017-01-11

Locations

2 sites across 1 country: United States