NCT01148043

Pharmacological Treatment In Osteoarthritis

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: Maasstad Hospital · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the efficacy of hydroxychloroquine in hand osteoarthritis.

Detailed description

Osteoarthritis is the most common joint disease, most frequently involving the hands, resulting in pain, stiffness and loss of hand function. At present, there is no option to prevent the onset or the progression of hand osteoarthritis (OA). It is believed that inflammation plays an important role in the pathogenesis of OA and that anti-inflammatory drugs might be an effective treatment for OA. Anti-malarial agents like chloroquine and hydroxychloroquine are potential anti-inflammatory drugs and hydroxychloroquine has already proven to be an effective suppressor of inflammation in rheumatoid arthritis. Several previous studies with hydroxychloroquine in hand OA also showed a possible effect on pain and inflammation, but these studies were mostly retrospective with a small number of patients. This is the first prospective, randomised, placebo-controlled study to determine the effect of hydroxychloroquine in hand osteoarthritis.

Conditions

• Osteoarthritis

Interventions

Type	Name	Description
DRUG	Hydroxychloroquine	200 mg capsule, 2 capsules QD for 24 weeks.
DRUG	cellulose	capsule, 2 capsules QD for 24 weeks

Timeline

• Start date: 2010-07-01
• Primary completion: 2014-06-01
• Completion: 2014-09-01
• First posted: 2010-06-22
• Last updated: 2015-04-13

Locations

6 sites across 1 country: Netherlands