Trials / Completed
CompletedNCT01146210
Identification of de Novo Fanconi Anemia in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia
Identification of de Novo Fanconi Anemia Patients Using FANCD2 Western Blots
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 20 (actual)
- Sponsor
- Children's Oncology Group · Network
- Sex
- All
- Age
- 21 Years
- Healthy volunteers
- Not accepted
Summary
This research study is studying identification of de novo Fanconi anemia in younger patients with newly diagnosed acute myeloid leukemia. Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to Fanconi anemia in patients with acute myeloid leukemia.
Detailed description
PRIMARY OBJECTIVES: I. Identify children with newly diagnosed acute myeloid leukemia (AML) treated on COG-2961 and COG-AAML03P1 who are at high risk of having de novo Fanconi anemia. II. Procure diagnostic samples from the COG AML Biology Repository and identify Fanconi anemia patients using western blot techniques. OUTLINE: Previously collected cryopreserved cells are analyzed via western blot to identify patients with Fanconi anemia.
Conditions
- Childhood Acute Erythroleukemia (M6)
- Childhood Acute Megakaryocytic Leukemia (M7)
- Childhood Acute Minimally Differentiated Myeloid Leukemia (M0)
- Childhood Acute Monoblastic Leukemia (M5a)
- Childhood Acute Monocytic Leukemia (M5b)
- Childhood Acute Myeloblastic Leukemia With Maturation (M2)
- Childhood Acute Myeloblastic Leukemia Without Maturation (M1)
- Childhood Acute Myelomonocytic Leukemia (M4)
- Childhood Myelodysplastic Syndromes
- Chronic Myelomonocytic Leukemia
- de Novo Myelodysplastic Syndromes
- Fanconi Anemia
- Refractory Anemia
- Refractory Anemia With Excess Blasts
- Refractory Anemia With Excess Blasts in Transformation
- Refractory Anemia With Ringed Sideroblasts
- Secondary Myelodysplastic Syndromes
- Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | laboratory biomarker analysis | Correlative studies |
Timeline
- Start date
- 2009-05-01
- Primary completion
- 2016-05-01
- Completion
- 2016-05-01
- First posted
- 2010-06-17
- Last updated
- 2016-05-17
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT01146210. Inclusion in this directory is not an endorsement.