NCT01138774

Effects of Lipoic Acid and Eicosapentaenoic Acid (EPA) in Human Obesity

Cellular and Molecular Effects of Lipoic Acid and Eicosapentaenoic Acid (EPA) on Adipose Tissue: Potential Application in Human Obesity

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 103 (actual)
• Sponsor: Clinica Universidad de Navarra, Universidad de Navarra · Academic / Other
• Sex: Female
• Age: 20 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The aim of the study is to analyze the effects of Lipoic acid and/or EPA supplementation on weight loss, lipid profile, insulin resistance, oxidative and inflammation parameters, metabolomic profile as well as on adipose tissue gene profile in healthy overweight/obese subjects following an energy-restricted diet.

Conditions

• Obesity
• Body Fat
• Insulin Resistance

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Double blind dietary intervention with EPA and lipoic acid	Placebo-controlled dietary intervention during 10 weeks. All groups will have a dietary treatment with a calorie restriction of 30 % the subject's energy expenditure at baseline, supplemented with eicosapentaenoic acid (EPA) and/or lipoic acid (LA).

Timeline

• Start date: 2010-01-01
• Primary completion: 2011-12-01
• Completion: 2012-12-01
• First posted: 2010-06-07
• Last updated: 2015-05-28

Locations

1 site across 1 country: Spain