NCT01137396

Modafinil, Sleep Architecture and Cocaine Relapse

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 114 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 25 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The medication modafinil has been shown to reduce cocaine use in some cocaine users. The investigators have shown that modafinil taken in the morning improves sleep in chronic cocaine users. The investigators hypothesize that the beneficial effects of modafinil in reducing cocaine use may be related to specific effects modafinil has on sleep. This study will measure sleep and cocaine use in cocaine dependent persons who are trying to stop using cocaine, and will test the connection between modafinil's effects on sleep and cocaine use.

Conditions

• Cocaine Dependence

Interventions

Type	Name	Description
DRUG	Modafinil	Modafinil 400mg PO QDaily following up-titration for \~8weeks
BEHAVIORAL	Cognitive Behavioral Therapy	Once weekly cognitive behavioral therapy for cocaine dependence

Timeline

• Start date: 2010-04-01
• Primary completion: 2015-02-01
• Completion: 2015-02-01
• First posted: 2010-06-04
• Last updated: 2016-04-27
• Results posted: 2016-04-27

Locations

1 site across 1 country: United States