Trials / Completed
CompletedNCT01137253
Autonomic Nervous System and Nitric Oxide Interactions
The Autonomic Nervous System, Nitric Oxide and TPA Interactions
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 21 (actual)
- Sponsor
- Vanderbilt University · Academic / Other
- Sex
- All
- Age
- 18 Years – 60 Years
- Healthy volunteers
- Accepted
Summary
The investigators are interested in the role of the autonomic nervous system in the regulation of endothelial function among obese hypertensive subjects. In particular, the investigators will study how endothelial function (response to intra-arterial acetylcholine) changes during autonomic withdrawal.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Trimethaphan | Trimethaphan 4 mg/min IV, for the duration of the study (approximately 2 hours) |
| DRUG | Placebo | Response to intrabrachial vasodilators during IV saline infusion |
Timeline
- Start date
- 2010-06-01
- Primary completion
- 2017-01-01
- Completion
- 2017-01-01
- First posted
- 2010-06-04
- Last updated
- 2018-02-28
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT01137253. Inclusion in this directory is not an endorsement.