NCT01134198

Investigation of Mifepristone (RU486) on Stress Sensitivity and Relapse Prevention in Cocaine Dependent Patients

Investigation of the Effects of Mifepristone (RU486) on Stress Sensitivity and Relapse Prevention in Cocaine Dependent Patients

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 58 (actual)
• Sponsor: New York State Psychiatric Institute · Academic / Other
• Sex: Male
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

This research will evaluate the impact of blocking central and peripheral glucocorticoid receptors on stress sensitivity and the risk of relapse to cocaine use in treatment-seeking cocaine-dependent individuals. Mifepristone (RU-486) will be the glucocorticoid antagonist used.

Detailed description

This study attempts to reduce relapse risk by blocking glucocorticoid receptors, and thus allow some of the changes in the brain caused by cocaine to redress themselves

Conditions

• Cocaine Dependence

Interventions

Type	Name	Description
DRUG	Mifepristone	Mifepristone 600mg, 3x/wk for 4 weeks
DRUG	placebo	placebo

Timeline

• Start date: 2010-05-01
• Primary completion: 2016-09-01
• Completion: 2018-02-14
• First posted: 2010-05-31
• Last updated: 2018-12-20
• Results posted: 2018-08-24

Locations

1 site across 1 country: United States