NCT01132053

Role of Inflammation in Progressive Multifocal Leukoencephalopathy (PML)

Role of Inflammation in PML

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 126 (actual)
• Sponsor: Beth Israel Deaconess Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a continuation of our previous studies on Progressive Multifocal Leukoencephalopathy (PML). We will focus on the role of inflammation in PML, and define prognostic markers of disease evolution.

Detailed description

To determine precisely what are the host or viral factors that may predict a favorable outcome for PML patients and the role of inflammation in preventing JCV from causing brain disease. One of the goals of this study is to help establish non-invasive markers of PML evolution by studying the brain metabolism in PML lesions using Magnetic Resonance Imaging (MRI), Magnetic Spectroscopy (MRS) and other advanced imaging modalities.

Conditions

• Progressive Multifocal Leukoencephalopathy

Timeline

• Start date: 2004-06-01
• Primary completion: 2016-09-01
• Completion: 2018-12-01
• First posted: 2010-05-27
• Last updated: 2023-08-14

Locations

1 site across 1 country: United States