NCT01130103

Combination Treatment for Posttraumatic Stress Disorder (PTSD) After the World Trade Center (WTC) Attack

Combination Treatment for PTSD After the WTC Attack

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 37 (actual)
• Sponsor: Research Foundation for Mental Hygiene, Inc. · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This randomized controlled trial evaluates efficacy of combined prolonged exposure (PE) and the selective serotonin reuptake inhibitor (SSRI) paroxetine in the treatment of survivors of the World Trade Center (WTC) attacks.

Detailed description

Selective serotonin reuptake inhibitor (SSRI) medication is often recommended in combination with cognitive behavioral therapies for PTSD, but combined initial treatment of PTSD has not been studied under controlled conditions. Also, there are few studies of either treatment in survivors of terrorism. This randomized controlled trial evaluates efficacy of combined prolonged exposure (PE) and the SSRI paroxetine in the treatment of survivors of the World Trade Center (WTC) attacks.

Conditions

• Posttraumatic Stress Disorder

Interventions

Type	Name	Description
DRUG	Paroxetine	Paroxetine (controlled release) 12.5-50 milligrams (mg) daily for 22 weeks
BEHAVIORAL	Prolonged Exposure Therapy	Weekly for 10 weeks

Timeline

• Start date: 2004-03-01
• Primary completion: 2010-02-01
• Completion: 2010-02-01
• First posted: 2010-05-25
• Last updated: 2012-12-04
• Results posted: 2012-08-14

Locations

1 site across 1 country: United States