NCT01114100

The Effects of Treatment With Sertraline for Noncardiac Chest Pain

The Effects of Treatment With Sertraline for Panic Disorder and/or Depression Driven Chest Pain and/or Palpitations in a Double Blind, Care as Usual and Placebo Controlled Study

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 210 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether care as usual or intervention (consisting of sertraline versus placebo), are effective in the treatment of panic disorder and/or depression driven noncardiac chest pain.

Detailed description

Noncardiac chest pain remains an important problem in clinical cardiology. Often, panic disorder and/or depression are the underlying cause. However, this is largely underdiagnosed. There are no clear existing treatment strategies/methods for this specific patient population. In our double blind, placebo controlled care as usual versus sertraline study, we want to investigate whether intervention is more effective as care as usual for diminishing chest pain, and also if sertraline is more effective in this specific population compared to placebo.

Conditions

• Panic Attacks
• Chest Pain
• Depression

Interventions

Type	Name	Description
DRUG	sertraline	starting dose 25 mg for 1 week, the increasing to 50 mg, after each visit evaluation whether dosage has to be increased to maximally 150 mg
DRUG	placebo	patients received 1 pill, according to their complaints the number of pills was increased to maximally 3

Timeline

• Start date: 2000-01-01
• Primary completion: 2002-12-01
• Completion: 2002-12-01
• First posted: 2010-04-30
• Last updated: 2010-05-18

Locations

1 site across 1 country: Netherlands