NCT01104194

Effects of Fish-oil on Mood and Cognitive Functions of Healthy Individuals

The Effects of Omega-3 Fatty Acids Dietary Supplements (Fish-oil) on Mood and Cognitive Functions of Healthy Individuals

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Leiden University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The investigators recently found a positive effect of omega-3 supplements on cognitive function in healthy individuals after 4 weeks (J of Psychopharmacology 2009, 23: 831-840). The investigators hypothesize that 4 weeks consumption of omega-3 supplements in previously depressed individuals will positively affect their cognitive functions. Secondly, low Heart Rate Variability (HRV) is a risk factor for cardiovascular disease. Some studies have found low HRV in patients with depression. No studies have investigated the effects of omega-3 fatty acid supplements on Heart Rate Variability in individuals with a history of depression. The investigators will test the hypotheses that omega-3 supplements lead to an improvement of heart rate variability indices in healthy volunteers with a history of depression.

Conditions

• Depression

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	omega-3 fatty acids supplements (fish oil)	1.74g eicosapentaenoic acid (EPA) and 0.25g docosahexaenoic acid (DHA)
DIETARY_SUPPLEMENT	Placebo	softgel capsules (identical in appearance to fish oil capsules) containing olive oil. 3 capsules/day, 4 weeks

Timeline

• Start date: 2008-09-01
• Primary completion: 2010-09-01
• Completion: 2010-09-01
• First posted: 2010-04-15
• Last updated: 2011-07-11

Locations

1 site across 1 country: Netherlands