Trials / Completed
CompletedNCT01102439
Clopidogrel/Aspirin Interaction Study
Randomized, Factorial Study to Explore Interaction Between Aspirin and Clopidogrel in Stable Patients With Previous Myocardial Infarction or Coronary Artery Stent
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 82 (actual)
- Sponsor
- Population Health Research Institute · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This study will explore the effect of different doses of aspirin on the effects of double-dose or standard dose clopidogrel.
Detailed description
Study Hypothesis: Patients receiving double-dose compared with standard-dose clopidogrel will have increased blood concentrations of the active metabolite of clopidogrel and greater inhibition of ADP-induced platelet aggregation when also treated with acetylsalicylic acid (ASA) 325 mg/d as compared to ASA 81 mg/d.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Clopidogrel | 300 mg loading dose, then 75 mg daily |
| DRUG | Clopidogrel | 600 mg loading dose, 150 mg daily day 2-7, then 75 mg daily |
| DRUG | Aspirin | 81 mg daily |
| DRUG | Aspirin | 325 mg daily |
Timeline
- Start date
- 2010-04-01
- Primary completion
- 2010-12-01
- Completion
- 2013-02-01
- First posted
- 2010-04-13
- Last updated
- 2015-04-28
Locations
1 site across 1 country: Canada
Source: ClinicalTrials.gov record NCT01102439. Inclusion in this directory is not an endorsement.