NCT01100996

Anti-inflammatory Effects of Enriched Enteral Nutrition During Human Experimental Endotoxemia

The Effect of Enriched Enteral Nutrition on Inflammation and Sub-clinical Organ Dysfunction During Human Endotoxemia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (estimated)
• Sponsor: Radboud University Medical Center · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

During sepsis and septic shock the immune response can be overwhelming leading to excessive tissue damage, organ failure and death. Ideally, the inflammatory response is modulated leading to both adequate protection to invading pathogens as well as limitation of an exuberant immune response. In the last years, experimental evidence has been accumulating that enteral administration of lipid-enriched nutrition attenuates inflammation and preserves organ integrity in several inflammatory models. The current study investigates the immune-modulating potential of enriched enteral nutrition in a human setting of experimental endotoxemia.

Conditions

• Endotoxemia

Interventions

Type	Name	Description
OTHER	control enteral nutrition	This feeding consists of 20en% fat, 16en% protein and 49en% carbohydrates
OTHER	enriched enteral feeding	This feeding contains 46 energy percent (en%) fat, 24en% protein and 30en% carbohydrates and is enriched with phospholipids.

Timeline

• Start date: 2010-02-01
• Primary completion: 2011-03-01
• Completion: 2011-04-01
• First posted: 2010-04-09
• Last updated: 2011-06-07

Locations

1 site across 1 country: Netherlands