Trials / Completed
CompletedNCT01060969
Tadalafil and Acetazolamide Versus Acetazolamide in Acute Mountain Sickness Prevention
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 55 (actual)
- Sponsor
- Sheba Medical Center · Other Government
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
To evaluate the additive value of tadalafil given together with Diamox (acetazolamide) in preventing acute mountain sickness in travelers to high altitude areas.
Detailed description
A randomized controlled study comparing: Tadalafil \[20mg x1/day\] and acetazolamide \[125mg x2 day\], versus Acetazolamide \[125mg x2 day\] alone, in trekkers to altitude \> 3,000 m.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Tadalafil and acetazolamide | Experimental arm: Tadalafil 20 mg daily + acetazolamide 125 mg BID beginning above 3000 m altitude. |
| DRUG | Acetazolamide | Active comparator arm (control): acetazolamide 125 mg BID beginning above 3000 m altitude |
Timeline
- Start date
- 2006-01-01
- Primary completion
- 2010-08-01
- Completion
- 2010-08-01
- First posted
- 2010-02-02
- Last updated
- 2012-09-10
Locations
3 sites across 1 country: Israel
Source: ClinicalTrials.gov record NCT01060969. Inclusion in this directory is not an endorsement.