NCT01059968

Low Energy Availability, Menstrual Irregularity, and Low Bone Mass

The Role of Low Energy Availability and the H-P-A Axis, Menstrual Irregularity, and Low Bone Mass

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 45 (actual)
• Sponsor: USDA, Western Human Nutrition Research Center · Federal
• Sex: Female
• Age: 15 Years – 17 Years
• Healthy volunteers: Accepted

Summary

This study examines the role of energy availability on menstrual function and bone mass in female adolescent endurance athletes. Specific evaluations include dietary intake, exercise energy expenditure, training schedules, menstrual function and bone density.

Detailed description

The purpose of this project is to examine the relationships among low energy availability, H-P-A axis, menstrual function and bone density and bone turnover in high school female cross country runners. Our objectives are to: 1)determine energy intake, exercise energy expenditure, and fat-free mass to examine energy availability; 2)in a subset of runners, using double labelled water, estimate total energy expenditure and indirect calorimetry to estimate resting metabolic rate; 3)assess the relationship between energy availability, hormones that regulate bone turnover, markers of bone formation and resorption and bone mineral content and density; 4)identify the relationship between energy availability, hormones that regulate menstrual function and current menstrual status; and 5)determine the energy intake and energy expenditure variables exhibiting the strongest associations with energy availability.

Conditions

• Bone Density
• Energy Availability

Timeline

• Start date: 2008-09-01
• Primary completion: 2008-12-01
• Completion: 2009-12-01
• First posted: 2010-02-01
• Last updated: 2011-06-23

Locations

1 site across 1 country: United States