NCT01051999

Glutamine Supplementation in Cystic Fibrosis

Glutamine Supplementation and Immunity in Adults With Cystic Fibrosis

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: Emory University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Patients with cystic fibrosis develop frequent and potentially life-threatening lung infections. Recent studies suggest that the nutrient "glutamine" may help the body fight off infection. Glutamine is an amino acid; a type of nutrient the body requires to build muscle. It is one of the building blocks of protein. During an illness, blood levels of glutamine tend to be lower than normal. Also, many patients with cystic fibrosis have difficulty getting normal levels of nutrients from food. The aim of this study is to see if patients with cystic fibrosis have low levels of glutamine when they experience an infection, and whether a dietary glutamine supplement taken daily for three months can raise these levels. We also want to see if this supplement can improve other blood markers of immunity (the body's ability to defend itself from infection). We hope to enroll 40 people with cystic fibrosis who experience a lung infection, over a one year period, into this study.

Conditions

• Cystic Fibrosis
• Immune Function

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Glutamine	Oral glutamine powder
DIETARY_SUPPLEMENT	L-alanine	L-alanine oral powder

Timeline

• Start date: 2010-02-01
• Primary completion: 2011-02-01
• Completion: 2011-02-01
• First posted: 2010-01-20
• Last updated: 2015-01-14

Locations

1 site across 1 country: United States