NCT01041989

Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,200 (estimated)
• Sponsor: Finnish Institute for Health and Welfare · Other Government
• Sex: All
• Age: 60 Years – 77 Years
• Healthy volunteers: Not accepted

Summary

This multi-center (6 sites: Helsinki, Kuopio, Oulu, Seinäjoki, Turku, Vantaa) intervention study aims to prevent cognitive impairment, dementia and disability in 60-77 year old persons at an increased dementia risk. The 2-year multi-domain life-style intervention includes nutritional guidance, exercise, cognitive training, increased social activity, and intensive monitoring and management of metabolic and vascular risk factors. The primary outcome is cognitive impairment measured by a sensitive Neuropsychological Test Battery (NTB), and Stroop and Trail Making tests to capture early cognitive impairment typical for both Alzheimer's disease and vascular dementia. We hypothesize that the multi-domain intervention will reduce cognitive impairment in the study group compared to the control group during the initial 2-year intervention period and reduce dementia incidence after the extended follow-up (until at least 300 participants have developed dementia).

Conditions

• Cognitive Impairment
• Dementia

Interventions

Type	Name	Description
BEHAVIORAL	Nutritional guidance	Individual counseling sessions and group meetings will be organized.
BEHAVIORAL	Exercise	Guided muscle strength training and aerobic exercise.
BEHAVIORAL	Cognitive training	Cognitive training will be implemented through 8 group sessions lead by a psychologist and a computer-based cognitive training program available to participants via the internet.
OTHER	Reduction of vascular risk factors	Monitoring and maintenance of metabolic and vascular risk factors

Timeline

• Start date: 2009-09-01
• Primary completion: 2013-12-01
• Completion: 2025-12-01
• First posted: 2010-01-05
• Last updated: 2023-04-19

Locations

5 sites across 1 country: Finland