NCT01041729

Long-term Pleiotropic Effect of Statins in Patients With Peripheral Arterial Disease

Phase IV Study of Statins for Assess the Long-term Pleiotropic Effect Upon Nitric Oxide and C-Reactive Protein Levels in Patients With Peripheral Arterial Disease

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Hospital Universitario Getafe · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the long-term effects of statins, atorvastatin, upon Nitric Oxide, as an endothelial function assessment, and C-Reactive Protein, an inflammatory marker, levels in patients with Peripheral Arterial Disease. These long-term biological pleiotropic effects of statins will offer information on the role of endothelial function and systemic inflammation in the etiopathogenesis of PAD.

Conditions

• Peripheral Arterial Disease

Interventions

Type	Name	Description
DRUG	Atorvastatin	Patients with Peripheral Arterial Disease in Fontaine Stage II treated with Atorvastatin 40mg/day during 12 months
DRUG	Standard Medical Treatment	Patients with Peripheral Arterial Disease in Fontaine Stage II without treatment with Atorvastatin 40mg/day during 12 months. Standard Medical Treatment.

Timeline

• Start date: 2008-01-01
• Primary completion: 2009-03-01
• Completion: 2009-06-01
• First posted: 2010-01-01
• Last updated: 2010-01-05

Locations

1 site across 1 country: Spain