NCT01038102

Role of Dietary Fatty Acids in Fatty Liver and Insulin Resistance

Role of Dietary Fatty Acids in Fatty Liver and Insulin Resistance: a Randomized Controlled Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 65 (actual)
• Sponsor: Uppsala University · Academic / Other
• Sex: All
• Age: 30 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate whether substituting saturated fats with polyunsaturated fats reduces fatty liver and improves insulin action and other metabolic variables in abdominally obese subjects

Detailed description

Specific goals: 1. Investigate if substituting saturated fats with polyunsaturated fats reduces steatosis and improves hepatic and/or peripheral insulin action in abdominally obese subjects with type 2 diabetes 2. Investigate if changes of lipogenic enzymes in response to dietary fat intervention are associated with changes in hepatic/peripheral insulin sensitivity or liver fat content 3. Investigate potential mechanism of the effects of dietary fatty acids; e.g. gene expression and lipogenic enzyme activity

Conditions

• Obesity
• Diabetes
• Insulin Resistance
• Fatty Liver

Interventions

Type	Name	Description
OTHER	PUFA Diet	Diet high in polyunsaturated (rich in linoleic acid, omega-6) fat (15 E%).
OTHER	SFA diet	Diet high in saturated fat (15E%)

Timeline

• Start date: 2009-02-01
• Primary completion: 2010-04-01
• Completion: 2010-04-01
• First posted: 2009-12-23
• Last updated: 2010-07-13

Locations

1 site across 1 country: Sweden