NCT01012843

Do Antibiotics Prevent Anal Fistulae Formation?

Does Adjuvant Antibiotic Treatment After Drainage of Anorectal Abscess Prevent the Development of Anal Fistulae? A Prospective Randomized, Placebo Controlled, Double Blind, Multi-Center Clinical Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 151 (actual)
• Sponsor: Ankara University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Purpose: This randomized study assesses the effects of antibiotics on the formation of fistulae after drainage of anorectal abscesses. Methods: Patients who underwent abscess drainage in 3 major colorectal units between September 2005 and January 2008 were included. Previous anorectal surgery history, immunecompromised states, pregnancy, inflammatory bowel disease, antibiotic usage prior to surgery and the presence of an anal fistulae at the time of surgery were the exclusion criteria. Patients were randomized and given either placebo or amoxicillin-clavulanic acid combination treatment for 10 days. Patients were followed one year for perianal fistulae formation.

Conditions

• Anal Fistula

Interventions

Type	Name	Description
DRUG	Amoxicillin-Clavulanate	oral 875/125 mg tablets of Amoxicillin/Clavulanate 2 times a day for 10 days
DRUG	Placebo	oral Placebo tablets two times a day for 10 days

Timeline

• Start date: 2005-09-01
• Primary completion: 2008-01-01
• Completion: 2008-01-01
• First posted: 2009-11-13
• Last updated: 2009-11-16

Locations

3 sites across 1 country: Turkey (Türkiye)