NCT00987441

Epidural Labor Analgesia and Infant Neurobehavior

Epidural Analgesia for Labor Pain and Infant Neurobehavior

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,200 (actual)
• Sponsor: Nanjing Medical University · Academic / Other
• Sex: Female
• Age: 19 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

Infant neurobehavior alteration is predictor of later intelligence development. Many factors would influence or are associated with infant neurobehavior, of which exist or appear during perinatal period. Neuraxial, especially epidural, analgesia to date is the most effective method in relieving labor pain. Although previous studies showed that opioid used in epidural analgesia for labor pain can affect newborn neurobehavior negatively in a dose-escalation associated manner, whether epidural analgesia itself would produce unpredictable effect on newborn neurobehavior is still unknown. Hereby the investigators designed this trial to investigate the hypothesis that epidural analgesia for labor pain control itself would not produce negative effect on infant neurobehavior.

Conditions

• Labor Pain

Interventions

Type	Name	Description
DRUG	Ropivacaine and sufentanil	Ropivacaine 0.125% plus sufentanil 0.3 microgram
DRUG	Ropivacaine and sufentanil	Ropivacaine 0.125% plus sufentanil 0.4 microgram
DRUG	Ropivacaine and sufentanil	Ropivacaine 0.125% plus sufentanil 0.5 microgram
DRUG	Ropivacaine and sufentanil	Ropivacaine 0.0625% plus sufentanil 0.4 microgram
DRUG	Ropivacaine and sufentanil	Ropivacaine 0.1875% plus sufentanil 0.4 microgram
DRUG	Ropivacaine and sufentanil	Ropivacaine 0.25% plus sufentanil 0.4 microgram

Timeline

• Start date: 2009-09-01
• Primary completion: 2011-07-01
• Completion: 2011-07-01
• First posted: 2009-10-01
• Last updated: 2011-07-27

Locations

1 site across 1 country: China