NCT00981786

24-Hour Intraocular Pressure With Brinzolamide/Timolol Versus Brimonidine/Timolol

Quality of 24-hour Intraocular Pressure Control Obtained With the Brinzolamide/Timolol Fixed Combination Compared With the Brimonidine/Timolol Fixed Combination When Added to Travoprost Monotherapy in Subjects With Open-angle Glaucoma

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 51 (actual)
• Sponsor: Aristotle University Of Thessaloniki · Academic / Other
• Sex: All
• Age: 29 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The proposed crossover study will compare for the first time the quality of 24-hour intraocular pressure control with the combination of travoprost and brinzolamide/timolol compared with travoprost and brimonidine/timolol in glaucoma patients insufficiently controlled with travoprost. This comparison may determine the real efficacy of the two fixed combinations when added to the prostaglandin. The design of the proposed study should facilitate a better understanding of the role of these medications in glaucoma management.

Conditions

• Glaucoma

Interventions

Type	Name	Description
DRUG	Brimonidine/timolol fixed combination drops added to travoprost	twice daily administration
DRUG	Brinzolamide/timolol fixed combination drops added to travoprost	twice daily dosing

Timeline

• Start date: 2009-08-01
• Primary completion: 2010-09-01
• Completion: 2010-12-01
• First posted: 2009-09-22
• Last updated: 2020-12-17